World Journal of Pharmacology and Toxicology
Open Access

Biography

After more than 6 years working as a surgeon at Shanghai in China, inspired by a strong desire to do basic biomedical research, I started my scientific career in 2000 and obtained my Master of Science degree for the Molecular and Cell Biology at National University of Singapore in 2002. However, the 6 years’ clinical experience and the sophisticated surgery skills that I have learned helped me a lot in my later animal research work. I did my post-doctoral training at University of Pittsburgh, where I have gained extensive experience on the regulation of cell death and autophagy in endotoxin-induced liver injury. I worked at the University of Kansas Medical Center in 2009 to study the role of autophagy in alcohol and drug-induced liver injury. During my postdoctoral training and later working at KUMC, I have not only vastly expanded molecular and animal experimental technical skills, but also have extensive experience and knowledge on cell death, autophagy and drug and alcohol-induced liver injury. I have so far published 49 papers in peer-reviewed journals. I served as a reviewer for more than 10 different peer-reviewed journals. My work has supported by several grants as principle investigator or co-investigator. In addition to research, I have demonstrated outstanding leadership for service. I became the technical director of the Cell Isolation Core in July 2015. As the technical director of the Cell Isolation Core, I am responsible for isolating primary human hepatocytes as well as mouse and rat primary hepatocytes and non-parenchymal cells, and provide the primary cells to all KUMC and KU campuses investigators. In addition to providing human and mouse/rat hepatocytes, I also provide technical instructions to the people who need help with the cell culture and experiment design as well as isolate hepatocytes and non-parenchymal cells from rodent livers.

Research Interest

1. Mechanisms of autophagy in drug-induced liver injury and targeting autophagy for drug-induced liver injury
2. Mechanisms of autophagy in alcoholic liver disease.
3. Mechanisms of hepatic ischemia and reperfusion injury

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