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Volume10, Issue 12 (Suppl) J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 85
conferenceseries.com
World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20th International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9th WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
The relationship of adiponectin, vitamin D, copper and zinc serum levels with rheumatoid arthritis
Nahid Kianmehr, Marya khajuinia, Anousheh Haghighi, Farhad Seif, Majid Khoshmirsafa and Maryam Hasani Nevisi
Iran University of Medical Sciences, Iran
Aim: To compare the serum levels of adiponectin, vitamin D, copper and zinc in rheumatoid arthritis (RA) patients and to
investigate the relationship between these factors and disease severity.
Method: Ninety patients with RA and 30 healthy individuals were participated in this study according to the ACR/
EULAR criteria for RA. Serum concentrations of adiponectin were determined by ELISA, copper and zinc by colorimetric
spectrophotometry and vitamin D by HPLC methods.
Results: Serum adiponectin and vitamin D were increased and decreased in RA patients, respectively. Adiponectin and disease
severity are positively correlated, whereas vitamin D and disease severity are negatively correlated. Adiponectin negatively
correlate with vitamin D and positively correlated with disease activity score (DAS). Copper and zinc showed no significant
difference between two groups.
Conclusion: The definitive roles of adiponectin, vitamin D, copper and zinc is not completely determined. More investigations
are needed to deeply explore the impact of them on RA pathophysiology. Finally, we suggest these serum factors as promising
diagnostic and therapeutic biomarkers.
Biography
Nahid Kianmehr is a member of Faculty of Iran University of Medical Sciences since 2000. His research interests include Internal Medicine and Rheumatology. He
is a Fellow of Emergency Medicine from George Washington University.
Nahid Kianmehr et al., J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-110