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Volume 8, Issue 2 (Suppl) J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal Neurology 2017
March 27-29, 2017
March 27-29, 2017 Madrid, Spain
11th World Congress on
Neurology and Therapeutics
Effectiveness of fingolimod in patients with relapsing-remitting multiple sclerosis in daily clinical practice
in Spain: Results from a multivariate pool analysis called Fingoview
Jose Meca-Lallana2, Guillermo Izquierdo 3, Celia Oreja4, Lucia Forero5, Teresa Ayuso6, Angel Perez Sempere7, Nicolas Herrera8, Javier Ricart9, Eli Garcia 9 and
Irene Sanchez-Vera9 on behalf of the investigators of the MS NEXT and MS SECOND LINE GATE studies
1Servicio de Neurologia. Hospital Universitario Miguel Servet. Zaragoza.
2Servicio de Neurologia. Hospital de Virgen de la Arrixaca. Murcia.
3Servicio de Neurologia. Hospital Virgen Macarena, Sevilla.
4Servicio de Neurologia. Hospital Clinico San Carlos. Madrid.
5Servicio de Neurologia. Hospital Universitario Puerta del Mar. Cadiz.
6Servicio de Neurologia, Hospital de Navarra. Pamplona
7Servicio de Neurologia, Hospital General de Alicante. Alicante
8Servicio de Neurologia, Hospital de Burgos. Burgos
9Novartis Farmaceutica S.A., Spain
Introduction: Once-daily Fingolimod (Gilenya®, Novartis Pharma AG) is a sphingosine 1-phosphate receptor modulator approved
for relapsing MS treatment. Continuous collection and analysis of real world effectiveness and safety data is the key to making accurate
treatment decisions. The objective is to describe basal characteristics and effectiveness of fingolimod in patients with relapsing-
remitting multiple sclerosis (RRMS) followed for ≥12 months in routine clinical practice in Spain.
Methods: Fingoview is a multivariate pool analysis of two observational, retrospective chart reviews, multicenter studies MS Second
Line Gate and MS Next, conducted in specialized MS centers in Spain, between November 2014 and December 2015. Pool analysis
was prospectively planned. Both studies included patients of both sexes, ≥18 years, diagnosed with RRMS, treated with fingolimod
according to SmPC and followed up for ≥12 months after treatment initiation.
Results: Fingoview included 988 patients (70 naïve, 252 post-natalizumab, 666 post first-line injectable DMTs), 68.9% female, mean
(SD) age: 40.44 (9.1) years. After 1, 2, 3 years of treatment, mean annual relapse rate decreased by 76.5% (mean: 1.19 to 0.28), 82.4%
(0.21) and 86.3% (0.16) compared to the year prior to fingolimod (all p<0.0001). At 12 months, 89.6% of patients had stable or
improved EDSS which was maintained in 84.4% of patients at 24 months. New/enlarged T2 lesions, gadolinium-enhancing lesions
on T1 or radiologically disease free will be discussed.
Conclusion: After switching to fingolimod, RRMS had significantly suppressed clinical disease activity and most of the patients have
a stable EDSS after one year of treatment.
Biography
Irene Sanchez-Vera completed her PhD in Neuropharmacology from Carlos Haya University Hospital (Malaga, Spain) and has been working as a Postdoctoral
Researcher at Carlos Haya University Hospital (Malaga, Spain), Principe Felipe Research Centre (Valencia, Spain), Andalusian Centre of Molecular Biology
and Regenerative Medicine (CABIMER, Seville, Spain), Institute de la Vision (Paris, France), University of Valencia (Spain), and Genetic Medicine Institute
(Newcastle upon Tyne, UK). Nowadays, she is a Medical Scientific Liaison at Novartis Farmaceutica (Spain). She has publications in reputed international journals
in Neuroscience field, and has been serving as Invited Referee in international journals
Jose Ramon Ara et al., J Neurol Neurophysiol 2017, 8:2 (Suppl)