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.com
Volume 8, Issue 3 (Suppl)
J Clin Cell Immunol, an open access journal
ISSN: 2155-9899
Euro Immunology 2017
June 29-July 01, 2017
June 29-July 01, 2017 Madrid, Spain
8
th
European
Immunology Conference
Anti-inflammatory effect of guggulsterone on inflammatory responses through ROS-HO-l axis
Sung-Joo Park, Gi-Sang Bae
and
Seung-Heon Hong
Wonkwang University, South Korea
G
uggulsterone (GS) is a phytosterol that has been used to treat inflammatory diseases such as colitis, obesity and thrombosis.
Although many previous studies have examined the anti-inflammatory activities of GS, the specific effect and mechanism of
GS on lipopolysaccharide (LPS)-induced inflammation and endotoxemia have not been examined. Therefore, we investigated the
anti-inflammatory action of GS on LPS-induced inflammatory responses on murine peritoneal macrophages and in septic mice. In
the mouse endotoxemia model, GS prolonged survival and inhibited inflammatory mediators such as interleukin (IL)-1β, IL-6 and
tumor necrosis factor-α (TNF-α) and also inhibited the organ injury. In murine peritoneal macrophages, GS significantly inhibited
production of nitric oxide (NOS) and COX-derived prostaglandin PGE2, as well as IL-1β and IL-6 and TNF-α. Furthermore, the
anti-inflammatory activities of GS were mainly through heme oxygenase-1 (HO-1) induction, which was mediated by GSH depletion
and ROS production from endoplasmic reticulum (ER). The ROS mediated by GS caused the phosphorylation of GSK3β (ser9/21)
and p38 and leads to translocation of nuclear factor (erythroid-derived 2)-like 2 (NRF2) which ultimately could induce HO-1. These
results suggest that GS exerts anti-inflammatory responses through ROS -HO-1 axis.
Biography
Sung-Joo Park is a Professor of Wonkwang University in South Korea, and majored in Korean Traditional Medicines and Immunology. He has many focuses on
inflammatory diseases such as pancreatitis, sepsis, obesity and asthma. He has many experimental models and molecule detection techniques to examine the
pathophysiology and possible drug of the diseases. Recently, he mostly studied about acute pancreatitis and sepsis and reported many papers about them.
parksj0822@daum.netSung-Joo Park et al., J Clin Cell Immunol 2017, 8:3(Suppl)
DOI: 10.4172/2155-9899-C1-037