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Volume 8, Issue 2 (Suppl) Chem Sci J 2017
ISSN: 2150-3494 CSJ, an open access journal Euro Chemistry 2017
May 11-13, 2017
May 11-13, 2017 Barcelona, Spain
4th European Chemistry Congress
Palladium catalyzed domino heck/aryne carbopalladation/c-h functionalization: Synthesis of heterocycle-
fused 9,10-dihydrophenanthrenes
Tuanli Yao
Shaanxi University of Science and Technology, China
Arynes generated from the corresponding o-(trimethylsilyl)aryl triflates have emerged as powerful synthons in organic synthesis.
Aryne annulation reactions with intramolecular C-H functionalization can be a powerful method for the synthesis of polycyclic
compounds. We developed a novel palladium-catalyzed domino Heck/aryne carbopalladation/C-H functionalization reaction using
in situ generated arynes, in which three new C-C bonds and a carbon quaternary center are formed. This methodology affords
moderate to excellent yields of heterocycle-fused 9,10-dihydrophenanthrenes.
Biography
Tuanli Yao has completed his PhD from Iowa State University and postdoctoral studies from University of California, Berkeley. He worked as Senior Scientist
at Deciphera Pharmaceuticals and Associate Researcher at University of Kansas before beginning his career in academy. Currently, he is professor at Shaanxi
University of Science & Technology. His research interests include aryne chemistry, electrophilic cyclization and palladium catalysis. He has published more than
30 papers in reputed journals.
Tuanli Yao, Chem Sci J 2017, 8:2(Suppl)