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Generally patients report the use of cannabis for medical purposes is to reduce pain and improve sleep. Despite this repeated association, it is not clear whether the effects of cannabis use on pain are mediated by the effect of improved sleep, or vice versa. This difference may have important therapeutic implications as different cannabis preparations have different pharmacokinetic properties; short acting cannabinoids may therefore initiate sleep but not maintain it, while longer acting cannabinoids may be better at sleep maintenance than initiation. Current reviews have examined the quantitative outcomes of sleep measures in clinical trials of cannabinoids in a range of disorders but did not focus on pain; others focused exclusively on one cannabinoid preparation.
Review Article: Sleep, Pain and Cannabis
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