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In 1998, the World Health Organization adopted the diagnostic parameters for diabetes established by the American Diabetes Association. Measuring the fasting blood glucose is considered to be the gold standard. These conventional laboratory methods employed to detect blood glucose are time consuming, invasive and require elaborative equipment. The advent of blood glucose monitors allows the clinician to assess blood glucose at the chair side. In contrast to laboratory method, results are obtained instantaneously, which helps the clinician to decide if further confirmatory tests are required to diagnose diabetes. Recently there has been an increasing evidence of research carried out to use gingival crevicular blood in monitoring blood glucose levels. The glucometer device may actually allow for painless testing of blood oozing from the gingival crevices of patients with periodontitis during routine periodontal examination and could be a simple and relatively inexpensive in-office screening device for any patient suspected to have diabetes. They can also be used to monitor blood glucose levels in known diabetics.