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Chronic myeloid leukemia (CML) has become a chronic and costly disease, since the launch and long-term use of tyrosine kinase inhibitors, including imatinib. Evidence for imatinib�s cost-effectiveness impact were largely based on preference-based quality of life (QoL) measured from randomized controlled trials, however, little is known aboutthe feasibility of QoL measured as a follow-up indicator in real life. This commentary describes our experiences inexploring the QoL measures and attributes influencing QoL in Taiwanese CML patients who were receiving imatinibtreatment.