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Zhou Zhou | OMICS International
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Zhou Zhou

China
Publications

Quantifying Induction/Inhibition Effects on Fuzuloparib Using a Physiologically Based Pharmaco-Kinetic (PBPK) model

Fuzuloparib was approved in China in 2020 for treating ovarian and other solid cancers in patients with germline BRCA (breast cancer gene) receiving second-line or above chemotherapy. It is a Poly Adenosine diphosphate-Ribose Polymerase (PARP) inhibitor developed by Jiangsu Hengrui Medicine Co., Ltd. PARP inhibits DNA repair in cancer cells, induce... Read More»

Jingxi Li, Keheng Wu, Xue Li, Sihui Long, Zhou Zhou, Youni Zhao, Ranran Jia, Pingping Song, Jack Liu and Bo Liu

: J Clin Exp Pathol

10.4172/2161-0681-22.12.415

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article

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