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Nigel Mackman
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Induced Activation of the Procoagulant Pathways and the Pathogenesis of Ischemia, Venous Thrombosis
A pathway is outlined through which diminished levels of oxygen activate the transcription factor early growth response-1 (Egr-1) leading to de novo transcription/translation of tissue factor in mononuclear phagocytes and smooth muscle cells, which eventuates in vascular fibrin deposition. The procoagulant response is magnified by concomitant suppr... Read More»
Shi-Fang Yan, Nigel Mackman, Walter Kisiel, David Stern and David Pinsky
: Atheroscler Open Access 2022, 7:5, 182
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