Biopolymers Research
Open Access

Nigel J Clayden

School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK.

Biography

Dr. Clayden studied for his B.A. in Chemistry at St Catherines College, Oxford University. Dr. Clayden's D. Phil., also from Oxford University, was concerned with shielding effects in NMR spectra and their use in conformational analysis. After a post-doctoral stint at MIT with Professor Waugh Dr. Clayden returned to Oxford University as a Shell Research Fellow. In 1986 Dr. Clayden joined ICI at the Wilton Research Centre where he managed a solid state NMR and materials NMR imaging. Dr. Clayden moved to UEA in 1994 where he is a member of the Molecular Structure Centre.

Publications

Conformational Dynamics in the Endonuclease Domain of Colicin E

The endonuclease domain of colicin E9 binds Zn2+ in a multi-step process with a substantial increase in stability that has been suggested to result partly from changes in the dynamic properties of the protein as detected by tryptophan fluorescence. We have used NMR and molecular dynamics to investigate the effect of zinc binding on the structure an... Read More»

Nigel J Clayden, Geoffrey R Moore, Emily S Collins and Ruth Boetzel

Research Article: Biopolymers Res 2017, 1: 103

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