Journal of Addiction Research & Therapy
Open Access

Jim R Fadel

Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, South Carolina, USA

Biography

Aging in general—and age-related neurodegenerative conditions (such as Alzheimer’s disease) in particular—is associated with changes in cognitive and homeostatic function. We are interested in how brain regions and neuropeptides important for arousal and homeostasis (such as the hypothalamic orexin/hypocretin system) regulate the activity of the basal forebrain cholinergic system, which is classically associated with age-related cognitive decline. We combine anatomical, neurochemical, molecular and behavioral approaches to understand how these systems interact and how they change with aging. In addition, we use these same tools in collaboration with colleagues to study the neural underpinnings of stress and anxiety.

Publications

Mechanisms and Mediators of the Relationship between Anxiety Disorders and Alcohol Use Disorders: Focus on Amygdalar NPY

High rates of co morbidity for Alcohol Use Disorders (AUDs) and anxiety disorders suggest a causative relationship between these disorders, as well as overlapping neurobiological mechanisms. While it is well established that alcohol withdrawal can precipitate and exacerbate the expression of anxiety, the extent to which pre-existing anxiety disorde... Read More»

Amanda C Sharko, Jim R Fadel and Marlene A Wilson

Research Article: J Addict Res Ther 2013, S4: 014

DOI: 10.4172/2155-6105.S4-014

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article

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