Clinical Pharmacology & Biopharmaceutics
Open Access

James R. Eckman

Grady Medical Center Atlanta GA, USA

Biography

James Eckman, MD, is Emeritus Professor of the Department of Hematology and Medical Oncology and held appointments as Professor of Medicine and Adjunct Professor of Pediatrics in Medical Genetics at Emory University School of Medicine. He was committed to establishing a sickle cell program at Grady Memorial Hospital, and after intensive state lobbying for funding in 1984, became Medical Director of the world's first 24-hour comprehensive acute care sickle cell center.

Publications

L-Glutamine Therapy Reduces Hospitalization for Sickle Cell Anemia and Sickle β°-Thalassemia Patients at Six Months – A Phase II Randomized Trial

Background: Increased oxidant stress plays an important role in the pathophysiology of sickle cell disease. Nicotinamide Adenine Dinucleotide (NAD) is an important anti-oxidant that protects hemoglobin as demonstrated in diseases such as methemoglobinemia. Early in-vitro studies have shown that L-glutamine, a precursor for NAD, reduced oxidant stre... Read More»

Yutaka Niihara, Henry Macan, James R. Eckman, Han Koh, Melanie L Cooper, Thomas R Ziegler, Rafael Razon, Kouichi R Tanaka, Charles W Stark and Cage S Johnson

Research Article: Clin Pharmacol Biopharm 2014, 3:116

DOI: 10.4172/2167-065X.1000116

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF