ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
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Ahrén B

Sölvegatan 19, Lund
Sweden
Publications

Stromal Derived Factor 1 alpha (SDF-1a) in a Dual Therapy with the DPP-4 Inhibitor 1 Vildagliptin does not Enhance Beta Cell Function but Improves Glucose Clearance after Oral Glucose in Streptozotocin Diabetic Mice

Pancreatic alpha cells secrete glucagon-like peptide 1 (GLP-1), the production of which is enhanced by the chemokine stromal derived factor 1 (SDF-1). Since SDF-1, like GLP-1, is a substrate of dipeptidyl peptidase-4 (DPP-4), we examined whether dual therapy with SDF-1 and a DPP-4 inhibitor would preserve beta cell function and mass in diabetes. Di... Read More»

Omara B, Liehuaa L and Ahrén B

Research Article: J Chem Biol Ther 2016, 1:110

DOI: 10.4172/2572-0406.1000110

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