Figure 4: Plasma Arginine metabolome reveals changes in methylation in CKD mice. ADMA, SDMA, NMMA levels, arginine, citrulline and arginine methylation index (ARG MI) were measured in plasma in control and CKD LDLr-/- mice by LC/MS. Bars represent mean ± SEM (n= 11 each group). Plasma ADMA (A), SDMA (B), ARGMI (D), arginine (E) and citrulline (F) are significantly higher in CKD mice. NMMA levels are not significantly different (C) (*p<0.05).