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Figure 4: miR-203 inhibits tumor growth in a xenograft mouse model. A, B. miR-203-expressing SKOV3, OVCAR3 and control cells were subcutaneously xenografted into immunodeficient NSG female mice and imaged at two weeks after injection by Xenogen live animal imaging. Tumor size was evaluated using the average maximal luminescence from 6 mice (*p<0.05). C. Tumor volumes in NSG mice xenografted with miR-203-expressing SKOV3 and OVCAR3 cells were measured using a caliper. (*p < 0.05; **p < 0.01). D. Tumors from NSG mice xenografted with miR-203-expressing SKOV3 and OVCAR3 cells were dissected and weighed (*p < 0.05; **p < 0.01). Significance was analyzed using Student’s T test. |