Figure 2: Mean bupropion and hydroxybupropion plasma concentration vs. time curve. A single oral dose administration of 150 mg bupropion tablet formulation (test or reference Zyban^®) was given to 78 volunteers divided in two groups. Group 1 was composed of 42 subjects (21 men and 21 female) and received the bupropion tablet without any special meal prior the drug administration. Group 2 was composed of 36 subjects (18 men and 18 female) and received the bupropion tablet after taken a hyperlipemic meal prior the drug administration. Panel (A) shows the bupropion plasma concentrations and panel (B) shows the hydroxybupropion plasma concentrations.