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| Figure 2: Duodenal enzyme concentrations and pH values in subject CF-. In Phase 1 (placebo+meal), the duodenal aspirate contained significant concentrations of all enzymes and the pH was increased due to the bicarbonate buffer content of the Placebo formulation. A steady increase in amylase and protease concentrations was observed with time. The pH was between 6.0 and 7.5 throughout the measurement interval. After administration of pancreatic enzymes in Phase 2 (EC-highbuffered pancrelipase+meal), the peak concentrations of protease and amylase were observed at 90 minutes postdose (at 330 min in Phase 2) and coincided with the peak pH of 7.5. Lipase concentration was variable, with no specific trend in relation to the pH. Arrows indicate time when all meal and study drug had been ingested and sample collection was started. Baseline concentrations are plotted at 240 min for Phase 2 |
