Figure 1: The chemical structure of emetine. Emetine is a
complex polycyclic molecule and could be obtained by methylation
of cephaelin. The radical CH3 as circled, is absence in
cephaelin (Lee, 2008). The (R)’ configuration at C-1’ and secondary
nitrogen atom at the 2’ position are necessary for
emetine’s activity (Grollman, 1966). |