Figure 3:Cross talk between oxidative stress, ER stress and immune System in melanocyte death: Decrease in antioxidant enzymes leads to ROS formation, ultimately leading to oxidative stress. Oxidative stress induces ER stress leading to activation of Unfolded Protein Response (UPR) which in turn activates autoimmune response. [Abbreviations: GPx (Glutathione Peroxidase), G6PD (Glucose 6 Phosphate Dehydrogenase), SOD (Superoxide Dismutase), LPO (Lipid Peroxidation), ROS (Reactive Oxygen Species), TNFA (Tumor Necrosis Factor- alpha), TNFB (Tumor Necrosis Factor - beta), IL1B (Interleukin 1-beta), NFkB (Nuclear Factor kappa – beta), IFNG (Interferon -gamma), UPR (Unfolded Protein Response), ERAD (Endoplasmic Reticulum Associated Degradation), LMP7 (Low Molecular Weight Polypeptide 7), TAP1 (Transporter Associated With Antigen Processing 1), Treg (T regulatory Cells), Teff (T effector cells), (Interleukins - IL6, IL8, IL10, IL17A), CTLA4 (Cytotoxic T Lymphocyte Antigen 4)]