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| Figure 1: A systems approach to identifying the molecular level causes of a particular disorder in a population. The approach involves sampling population comprising of healthy (control group shown in green) and diseased group (shown in blue, along with those suffering from a different disorder than that being studied - shown in red) suffering from a particular disease under study. The population is probed for genetic variation, gene expression signature variation within the context of the various cellular networks which are perturbed in a diseased group (and hence are responsible for the diseased phenotype) in order to identify the set of cellular entities which need to be modulated to achieve a desired state representing a signature similar to the healthy individuals. Such a process can be iterative to identify the specific drugs which can be functional and can be personalized to the individual to the extent of specific to particular tissues or organs the disease is bound to occur. |
