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| Figure 2: NLGN3&4–NRXN1–SHANK3-CNTNAP2 are important in the stability of synaptic function and also has a role in social involvement. NLGN3&4: are post synaptic proteins that bind with SHANK3, Neuroligin-neurexins regulate synaptic plasticity by control of the generation of excitatory and inhibitory synapses in vitro [16]. NRXN1: is presynaptic in that it binds with NLGN. Binding of NLGN-NRXN is mediated synaptic development. Therefore, it promotes the synaptic formation. SHANK3: is postsynaptic protein, connected the receptors in postsynaptic membrane to the cytoskeleton and have a role in the signalling pathway that regulating the shape and size of dendritic synaptic NLGN. CNTNAP2: presynaptic protein, it is highly restricted to frontal and interior temporal lobes striatum and dorsal thalamus [26]. |
