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| Figure 1: Schematic diagram of the physiological based pharmacokinetic model for BMP2 in mice. The ten compartments are modeled as continuous stirred tank reactors, and have uniform concentrations. These organs are characterized by their concentration of BMP2 (c), BMP2 turnover (PT), blood flow rates (Q) and the concentration of BMPRIa. The tissue compartments are numbered from #1 (brain) to #9 (fat) with #10 being blood. |
