Figure 1: Normal Prostate Epithelium. (A)Shows well stained prostate epithelium with neatly arranged fibromuscular stroma arrowed as white with no infiltration. Well defined glands with lumen as well as clearly seen nucleoli. (B) Gleason Pattern two representative of a well differentiated tumour with larger and darker purple coloured nuclei than the normal. Circled areas show well defined lumens easily seen with little infiltration of stroma to lumen. (C) Demonstrates Gleason Pattern 5 representative of a poorly differentiated tumour circled in red. Lumen is completely infiltrated by stroma with no glands as compared to the benign to normal prostate circled in green with clearly defined lumen. (D) Area Demarcated as green shows arrows demonstrating infiltration of the stroma into the lumen. Compared to Pattern 2 above, lumen is reducing in size and no longer forming nodules.