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| Figure 1: Impact of anatabine on the incidence of paralysis and abnormal hind-limb extension reflex in Tg Tau P301S. Representative Tg Tau P301S mice pictures showing a mouse with a normal hind-limb reflex (a) when suspended by the tail, an animal with a partial hind-limb extension reflex (b) and one mouse with a complete absence of extension reflex in both hind-limb (c). The histogram represents the proportion of Tg Tau P301S with complete posterior hind-limb paralysis and the proportion of non-paralyzed mice showing an abnormal hind-limb extension reflex in the placebo and anatabine treatment groups after 39 days of treatment. |
