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| Figure 3: NFE2L2-KEAP1 mechanism for antioxidant gene activation. NFE2L2 remains in complex with KEAP1 and stays in the cytoplasm. Oxidative stress (ROS) interacts with the KEAP1 complex (with RBX1 and CUL2) and releases NFE2L2. Free NFE2L2 is being phosphorylated and travels to the nucleus to bind ARE carrying sequences of the antioxidant genes, such as catalase and activates transcription. |
