Figure 6: Schematic representation of the human FBXW7 gene and the SCFFBXW7-E3 ligase complex. FBXW7 stretches on chromosomal region 4q.31.3 and encodes for 3 isoforms which share 10 common exons and differ in their first isoform-specific exon. All isoforms are functionally identical and form the substrate recognition component of the SCF complex. The FBXW7 protein consists of 627 amino acids and contains 3 main domains: a dimerization doman (DD), an F-box domain and a stretch of eight WD40 repeats domain. (Kemp, et al. [25]; Nakayama and Nakayama (2006) [35]. FBXW7 bridges the interaction between the substrates and the core SCF component mediating ubiquitin tranfer from E2 to the target protein. The F-box domain enables recruitment of the SCF complex via interaction with SKP1, and the WD40 complex mediates interaction with the phosphorylated substrates. (Nakayama and Nakayama (2006); Hoeller and Dikic [29]; Babaei-Jadidi, Li et al. (2011) [28]). FBXW7 substrates consist of oncoproteins implicated in human tumorigenesis such as growth promoters and EMT inducers as listed above.