Figure 2: Bodyplethysmographie at primary diagnosis (2013) and after manifest pulmonary toxicity (2015) showing massiv worsening of pre-existing restrictive lung disease as such small vessel disease. Legend: iVC=inspiratory vital capacity; FVC=forced vital capacity; FEV1=one second capacity; MEF 50=mean expiratory flow; RV=residual volume; TLC=total lung capacity, DLCOc=diffusing capacity.