Figure 2: Synthesis of Sphingosine-1-phosphate (S1P). A) S1P is formed from the union of Serine and Palmitoyl-CoA mediated by serine palmitoyl transferase (SPT). Serine gives carbons 1 and 2 for 3-Dehidroesfingosina molecule. Palmitoyl-CoA provides the others carbons. To perform the transfer of carbons thioester bond rupture of Palmitoyl-CoA and release Serine COO- group is required. As a result a CO2 molecule, a coenzyme A (CoA) and 3- Dehidroesfingosina is obtained. B) NADPH is required to reduce the carbonyl group at the 3-Dehydroesphingosine and is converted to dihydrosphingosine. FAD and FADH2 generated sphingosine. SphK 1 and 2 phosphorylate sphingosine and S1P is obtained.