Figure 2: Chemical structures of statins lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, pitavastatin, and rosuvastatin, and the enzyme substrate HMG-CoA. Statins contain an analogue of the target enzyme substrate HMG-CoA, a complex hydrophobic ring that is covalently linked to the substrate analogue and is involved in the statin´s binding to the HMGR.