Figure 6: Fusion of the N-terminal portion of EML4 to the intracellular region of ALK. The inversion within the short arm of chromosome 2 was found to result in the ligation of EML4 and ALK, leading to the production of a fusion protein consisting of the EML4 and the intracellular region of the protein tyrosine kinase ALK. This portion of EML4 mediates the constitutive dimerization and activation of EML4-ALK. TM: transmembrane domain.