Figure 3: Beta-oxidation pathway. The coordinated increase of seven enzymes that are key regulators of beta-oxidation of fatty acids, were found in apoptotic CGCs: Acadl (acyl-CoA dehydrogenase, long chain), Acsl1 (acyl-CoA synthetase long-chain family member 1), Cpt1a (carnitine palmitoyltransferase 1a), Cpt1b (carnitine palmitoyltransferase 1b), Cpt2 (carnitine palmitoyltransferase 2), Decr1 (2,4-dienoyl CoA reductase 1), and Eci1 (enoyl-CoA delta isomerase 1). Differentially expressed genes are highlighted in yellow and their expression in four experimental conditions are indicated with bar graphs (Control 3 h, first bar in red; -KS 3 h, second bar in orange; Control 6 h, third bar in yellow; -KS 6 h, fourth bar in grey). |