Figure 2: miR33 limits the mobilization of sterols in hepatocytes through both the sinusoidal and canalicular membrane. [139] A) miR33 mediates the crosstalk between the SREBP-2, LXR, FXR pathway by directly modulating the expression of ARP8B1, ABCB11, ABCA1and ABCG1 in mice. Decreased ATP8BP1activity in humans but not in mouse, hepatocytes, results in PKCdepedent inactivating phosphorylation of FXR. B) During episodes of low cholesterol or following treatment with statin drugs, miR33 is transcriptionally induced and reduces the expression of sterol transporters.