Figure 2: The IRF family members: function and alteration in tumors. Summary of main functional characteristics of each member of the IRF family. Functional domains, in particular the conserved tryptophan repeats (WWWWW) in the DNA-binding domain and the IRF association domain (IAD) are indicated. A summary of IRF functions in oncogenesis and altered expression in human malignancies is also provided. Colors distinguish differential expression of the proteins in pathological conditions (green: decreased; red: increased; black: not altered/undefined).