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| Figure 3: The model of Acanthamoeba granulomatous encephalitis. Amoebae enter lungs via the nasal route. Next, amoebae traverse the lungs into the bloodstream, followed by haematogenous spread. Finally, Acanthamoeba cross the blood-brain barrier and enter into the central nervous system (CNS) to produce disease. It is noteworthy that Acanthamoeba may bypass the lower respiratory tract and directly enter into the bloodstream via skin lesions. The olfactory neuroepithelium may provide an alternative route of entry into the CNS [27]. |
