Figure 2: PTEN mutations in HNSCC. A. Analyses of the mutations sites are shown in the exons and introns of the PTEN gene. B. Nonsynonymous mutations affecting the PTEN protein are clustered mostly within functional area of the phosphatase domain, between the active site cysteine residues 71 (C71) and 124 (C124). Additional mutations were in the C2-domain between the amino acids 192 and 350.