Figure 1: The structure of Progranulin: The upper panel shows that progranulin is a glycoprotein that is composed of seven and a half repeats of the granulin/ epithelin module designated A to G. P represents paragranulin, a six cysteine half module. The conserved amino acids of the granulin/epithelin module are shown (where C is cysteine, G is glycine, T is threonine, D is aspartic acid, P is proline and H is histidine. Dots represent amino acid residues that are not highly conserved). The lower panel shows that progranulin can be converted to peptide fragments each of about 6kDa that correspond to the granulin/epithelin modules.