Figure 3: CD40 activated pathways in bone marrow derived myeloma cells. Activation of CD40 on myeloma cells may exert antiapoptotic molecules (mostly belonging to IAP family) and antiapoptotic pathways and lead to enhanced secretion of proinflammatory (IL-6) and proangiogenic (TGFβ1, VEGF) cytokines which are responsible for increased tumor growth, survival, migration and angiogenesis.