A) Donor female SJL/J mice were immunized s.c. with 400 μg bovine MBP and 60 μg Mycobacterium tuberculosis in IFA. On 12th day of immunization, mice were perfused and splenic sections were double-immunolabeled for iNOS and CD11b. B) Splenic sections of male and female PLP-TCR transgenic mice (4 weeks old) were double-immunolabeled for iNOS and CD11b. Results represent analysis of four separate splenic sections from each of five different mice (n=5) per group.

Figure 1: Myelin protein priming induces the expression of iNOS in vivo in the spleen of donor mice