Figure 3: MRM LC-MS/MS chromatograms of a) PPG in blank rat plasma b) CrEL-PEG in rat blank plasma c) PPG spiked at 10 μg/mL concentration in rat plasma d) Rat plasma sample spiked with 1.00 μg/mL of CrEL-PEG e) plasma sample obtained 0.50 hr after intravenous administration of CrEL to SD rats f) plasma sample obtained 0.50 hr after oral administration of CrEL to SD rats. |