Figure 2: Schematic illustration of different formats of IgG-like bispecific antibodies.The parental monoclonal antibodies are represented above. (A) Heterodimeric functional bispecific antibody obtained with the Quadroma approach. (B) Bispecific antibody designed with the “Knobs-into-holes approach. (C) Bispecific antibody obtained with the CrossMAb approach. The three possible formats are represented with different light chain domains crossover. (D) Dual-Variable-Domain immunoglobulin (DVD-Ig) bispecific antibody with two variable domains.