Figure 2: Topical fenofibrate does not cause abnormalities in the anterior or posterior segment in rats. Normal Brown Norway rats were treated with the vehicle or fenofibrate eyedrops (30 μl/eye, 4 times/day for 4 weeks). (A) Representative TUNEL assay analysis of retinal cells apoptosis. Ocular section of human DR patient served as positive control. (B) Representative ocular sections of anterior segments of eyes. (C) Normal adult rats were treated with the vehicle or fenofibrate eyedrops (30 μl/eye, 1 dose), and PBS served as the control. The Schirmer tear test was performed at 0, 1 h, 2 h and 24 h following eyedrop application. (D) The lengths of the phenol red threads were averaged and compared. The Schirmer tear test was performed at 0, 1 h, 2 h and 24h following eyedrop application (mean ± SD, n=7).