Figure 1: Pedigrees of 11 families with retinitis pigmentosa and RP1 mutations. Squares indicate male, circles indicate female. Blackened symbols are individuals affected with RP. A double horizontal line between the mating pair indicates consanguinity. M means mutated allele (refers to Table 1 for mutation description), + means wild type allele. Patient numbers indicate generation in roman typeset and order in generation in arabic typeset. RP94 and RP494 are consanguineous families with autosomal recessive retinitis pigmentosa; the 9 other retinitis pigmentosa families show autosomal dominant inheritance.