Figure 1: CM images (0.5 x 0.5 mm) of normal skin. (A) Stratum corneum appears as highly refractile surface with dark skin folds. (B) Stratum granulosum has a regular honeycomb pattern and shows polygonal keratinocytes with grainy cytoplasms and dark central nuclei (arrows). (C) Stratum spinosum has a honeycomb pattern and spinous keratinocytes are smaller with dark central nuclei surrounded by a rim of bright cytoplasm (arrows). (D) Stratum basalis consists of a cobblestone pattern formed by clusters of small bright cells usually without nuclei visualized (asterisks). (E) Dermoepidermal junction consists of dermal papillary rings (arrows) surrounding dermal papillae (asterisks). (F) Papillary dermis consists of a network of reticulated grey fibers (asterisk), with central capillary vessels surrounded by bright cellular rings (arrows) correlated with basal keratinocytes.