Figure 1: Increased sensitivity of Nrf2 KO mice to STZ-induced diabetic lesions. Eight-week-old male WT and Nrf2 KO mice were treated with 0.1 M citrate buffer (n = 8), STZ (150 mg/kg body weight, n = 8), or STZ plus insulin (n = 4). Tail blood glucose level was monitored for diagnosis of diabetic conditions. Mortality was monitored daily for 14 days. (A) Mortality at day 14. (B) Time curve of percent survival. In (B), mortality was observed only in the group of KO+STZ.