Figure 5: Simplified process of glyceroneogenesis in adipocytes and its regulation by PEPCK-C. Lipolysis releases glycerol and fatty acids from triglyceride stores in fat cells. Fasting increases PEPCK-C production and fatty acid release is restrained due to increased glyceroneogenesis and reesterification in triacylglycerols, which requires glycerol-3-phosphate formation from non-carbohydrate precursors [766].