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| Figure 1: Diagrammatic representation of the role of the Rho/Rho-kinase pathway in airway smooth muscle contraction. Abbreviations: GTPactivating proteins; PLC, phospholipase C; DAG, diacylglycerol; MLC, myosin light chain; MLCK, myosin light chain kinase; MLCP, myosin phosphatase;Y-27632 and Fasudil, Rho-kinase inhibitors; IP3, inositol (1,4,5)-trisphosphate (Modified from Nagaoka et al., 2005). |
