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Figure 1: The habenula and connecting structures. Several areas confer input to the habenule through the stria medullaris (sm). The external part of the fasciculus retroflexus (E.fr) connects the lateral habenula (LHb) to the locus coeruleus (LC), to the raphe nucleus (RN), and via the rostromedial tegmental nucleus (RMTg) to the ventral tegmental area (VTA). The internal part of the fasciculus retroflexus (I.fr) connects the medial habenula (MHb) to the interpeduncular nucleus (Ipn). Medial to lateral habenula connections and Ipn to VTA connections are depicted in red: these connections are hypothesized to be important but their significance is not clear.
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