Verrucous carcinoma is a rare, extremely well differentiated squamous carcinoma with low clinical malignant potential first described in 1948 in the oral cavity. Since then, it has been described in other sites, such as the anus, penis, and the female genitalia. Based on the literature, verrucous carcinoma accounts for approximately 3-8% of all penile cancers and 20% of verruciform lesions of the penis, which also include giant condyloma (Buschke-Löwenstein), warty carcinoma and papillary Squamous Cell Carcinoma (SCC). In the World Health Organization (WHO) classification, each verruciform lesion is clearly defined with histological criteria and verrucous carcinoma is considered a distinct pathological entity separate from the other verruciform tumors. However, the term ââ¬Åverrucous carcinomaââ¬Â has been used for giant condyloma (Buschke-Löwenstein) and warty carcinoma in past literature, and thus, the true frequency of verrucous carcinoma may be lower than generally assumed.
Last date updated on January, 2025
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