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Intravenous dexmedetomidine is been increasingly used in perioperative setting including as an adjunct to local anaesthetic in various regional techniques with an intent either to improve the block quality, to increase the duration of block or to provide sedation and patient comfort during the periblock period. Intravenous dexme.. Read More
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Development of Opioid Tolerance and Endoplasmic Reticulum Stress
Opioids are potent analgesics, widely used to control acute and chronic pain. While repeated administration of opioids, particularly morphine, induces tolerance that reduces the effectiveness of the analgesic, the precise molecular mechanism for the development of tolerance remains uncertain. Opioids bind to the μ opioid rece.. Read More
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The symptoms that arise as a result of compression of brachial plexus, subclavian artery and veins at the thoracic outlet are called Thoracic Outlet Syndrome (TOS). TOS is one of the most controversial subjects in clinic practice. The treatment method of this syndrome is required to be based on a multidisciplinary approach, but .. Read More
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Investigating a Model for Acute Ischemic Pain in Humans
Background: The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies. We examined whether peripheral nerve damage and acute inflammation occur during short episodes of ac.. Read More
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Whole Body Vibration: An Effective Treatment for Painful Diabetic Neuropathy
Introduction:Painful diabetic neuropathy is a common complication of diabetes that affects multiple aspects of patients’ lives, severely limiting daily functions and quality of life. The aim of this case study was to evaluate the efficacy of whole body vibration (WBV) to reduce pain and thereby improve quality of life, wal.. Read More
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Immune Network, the Dangerous Liaisons in Pain: A Short Review
Introduction: Pain has increasingly become an important health problem. However, few doctors at primary health care are qualified to treat it. Recent researches also suggest that neurons are not the only ones involved in the establishment and maintenance of pain. This short review was conceived to collect some information on the.. Read More
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Intrathecal Morphine Therapy for Chronic Non-malignant Pain Using a Constant Flow Infusion System
Background: Implantable pumps for intrathecal opioid therapy in the last decades emerged as one of the most effective treatment for chronic non-malignant pain (CNMP) in selected patients. This study analyses reliability of intrathecal infusion morphine therapy for chronic and refractory pain not related to malignancy using an im.. Read More
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New and Emerging Treatments for Migraine
Migraine can be extremely disabling with a considerable impact on the life of an individual in their ability to work or perform activities of daily living. The arrival of ‘triptans’ in the early 1990s saw a major change in the way migraines were treated, and ‘triptans’ remain the gold standard in treating.. Read More
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Background: Spinal cord stimulation (SCS) is a safe and effective treatment for refractory failed back surgery syndrome (FBSS). Two implantation procedures exist depending on the use of a surgical versus percutaneous lead. Percutaneous leads implantation is less invasive but the placement procedure requires a higher X-ray exposu.. Read More
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Adolescent idiopathic scoliosis (AIS) is a common disease managed by pediatric orthopedic physicians. Current management is limited in objective measures, the mainstay being static radiographic evaluation of the Cobb angle. In this short commentary, we propose the use of video analysis software (VAS), specifically Dartfish Prosu.. Read More
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Objective: The indication of spinal cord stimulation (SCS), a treatment for intractable pain, has been expanded to include pain due to peripheral arterial occlusive disease (PAOD). However, its effectiveness may be influenced by the presence of some medical backgrounds. Then, the influences were analyzed in the current stud.. Read More
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Background: Chronic low back pain (CLBP) is highly prevalent, and between 35% and 55% of individuals with CLBP suffer from a neuropathic pain component (CLBP-NeP). Limited data on the economic and patient burden in this CLBP subgroup have been published. Methods: This observational study aimed to characterize burden a.. Read More
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Risk Factors for Chronic Low Back Pain in Adults: A Case Control Study Done in Sri Lanka
Introduction: Not many risk factor studies for low back pain have been done in Sri Lanka. Objectives: To determine the association between low back pain and posture, exercise, family history, level of education, level of income, smoking, consumption of alcohol, body mass index (BMI) and consumption of animal proteins... Read More
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Efficacy of Myofascial Release Method on Pain and Disease Severity in Patients with Fibromyalgia
Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread muscle pain and tender points. Aerobic exercises, antidepressants, electrotherapy, acupunctur, psychotherapy, behavior therapy, massage used alone or in conjunction with one another, may provide some relief of clinical features. The study was .. Read More
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Incidental Finding of Froin Syndrome during Spinal Anesthesia in a 72-Year-Old Patient
Froin Syndrome is characterized with xanthochromic CSF, high CSF protein content, complete blockage of CSF circulation. We reported our case of Froin Syndrome, a quite rare entity, with its radiologic features and characteristics of CSF biochemistry in the light of literature... Read More
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Objectives: We aimed to determine the correlation of radiographic contrast material distribution with selective lumbosacral nerve root block (SLNRB)-induced radiating pain and pain reduction obtained 3 ± 1 hours after SLNRB. Patients were stratified according to the distribution of contrast material: those in whom n.. Read More
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Inter-rater Reliability of Needle Electromyographic Findings in Patients with Sciatica
Purpose: Investigate inter-rater reliability of needle electromyographic findings among experienced physical therapist electromyographers. Methods: Masked review of 24 electromyographic recordings from patients with sciatica referred to physical therapy was undertaken. An examiner unmasked to patient history and physical examin.. Read More
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Habituation and sensitization are two fundamental consequences in response to repeated painful stimulation. However, individual differences as to who systematically habituate versus sensitize are currently not well understood. Investigating changes in response modulation (habituation and sensitization) in laboratory subjects und.. Read More
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Randomized Controlled Trial versus Real-World Study in Postherpetic Neuralgia
Background: Potential flaws in the design of randomized controlled trials (RCTs) and their low generalizability to clinical practice are being increasingly discussed. As some recent RCTs in neuropathic pain, including postherpetic neuralgia (PHN), demonstrated moderate or no treatment effect, better understanding of factors that.. Read More
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Introduction: Pain as one of the most common reason why people visit emergency room after fracture and soft tissue injury due to trauma. Thus, it should be assessed and managed well, particularly on its acute presentation. Adequate analgesia and early reduction should be done to decrease the severity of pain and minimi.. Read More
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